First Name: Robert M.Last Name: CaudlePublications: YearPublication 1982"Preparation of propyl N,N-diethylsuccinimate: An insect repellent" in Journal of Chemical Education 1987"Intrathecal dynorphin (1–13) results in an irreversible loss of the tail-flick reflex in rats" in Brain Research 1988"A novel interaction between dynorphin(1–13) and an N-methyl-d-aspartate site" in Brain Research 1988"Influence of dynorphin (1-13) on spinal reflexes in the rat" in The Journal of Pharmacology and Experimental Therapeutics 1990"Mu opioid receptor activation reduces inhibitory postsynaptic potentials in hippocampal CA3 pyramidal cells of rat and guinea pig" in The Journal of Pharmacology and Experimental Therapeutics 1990"Stimulation of endogenous opioid release displaces mu receptor binding in rat hippocampus" in Neuroscience 1990"Chronic morphine exposure blocks opioid effects on both the early and late inhibitory postsynaptic potentials in hippocampal CA1 pyramidal cells" in Neuroscience Letters 1991"Endogenous opioids released from perforant path modulate norepinephrine actions and inhibitory postsynaptic potentials in guinea pig CA3 pyramidal cells" in The Journal of Pharmacology and Experimental Therapeutics 1992"Kappa-opioids decrease excitatory transmission in the dentate gyrus of the guinea pig hippocampus" in Journal of Neuroscience 1992"Endogenous opioid regulation of norepinephrine release in guinea pig hippocampus" in Neuroscience Letters 1993"The demonstration of long latency potentials in the CA1 region of the rat hippocampal slice" in Brain Research 1993"The misuse of analysis of variance to detect synergy in combination drug studies" in Pain 1994"Fostering Young Investigators" in Science 1994"Kappa 2 opioid receptors inhibit NMDA receptor-mediated synaptic currents in guinea pig CA3 pyramidal cells" in Journal of Neuroscience 1997"Good Pain, Bad Pain" in Science 1997"Putative kappa-2 Opioid Agonists Are Antihyperalgesic in a Rat Model of Inflammation" in The Journal of Pharmacology and Experimental Therapeutics 1997"Activation of Spinal kappa2 Opioid Receptors" in Emerging Therapeutic Targets 1997"GR89,696 Is a Kappa-2 Opioid Receptor Agonist and a Kappa-1 Opioid Receptor Antagonist in the Guinea Pig Hippocampus" in The Journal of Pharmacology and Experimental Therapeutics 1998"Ifenprodil blocks the excitatory effects of the opioid peptide dynorphin 1–17 on NMDA receptor-mediated currents in the CA3 region of the guinea pig hippocampus" in Neuropeptides 1998"Adenoviral gene transfer to spinal cord neurons: intrathecal vs. intraparenchymal administration" in Brain Research 1998"Spinal k1 and k2 opioid binding sites in rats, guinea pigs, monkeys and humans" in NeuroReport 1999"The kappa opioid agonist GR89 696 blocks hyperalgesia and allodynia in rat models of peripheral neuritis and neuropathy" in Pain 1999"Actions of intrathecal diphtheria toxin-substance P fusion protein on models of persistent pain" in Pain 2000"Dynorphin: friend or foe?" in Pain 2000"Co-localization of N-methyl-d-aspartate receptors and substance P (neurokinin-1) receptors in rat spinal cord" in Neuroscience Letters 2001"Intrathecally administered cholera toxin blocks allodynia and hyperalgesia in persistent pain models" in The Journal of Pain 2001"Ligand-induced Dynamic Membrane Changes and Cell Deletion Conferred by Vanilloid Receptor 1" in Journal of Biological Chemistry 2002"Measurement of resiniferatoxin in cerebrospinal fluid by high-performance liquid chromatography" in Journal of Chromatography B 2003"N-Methyl-d-aspartate receptor subunit expression and phosphorylation following excitotoxic spinal cord injury in rats" in Neuroscience Letters 2003"Resiniferatoxin-Induced Loss of Plasma Membrane in Vanilloid Receptor Expressing Cells" in NeuroToxicology 2004"Receptor of advanced glycation end product (RAGE) expression in the minor salivary glands of patients with Sjögren's syndrome: a preliminary study" in Scandinavian Journal of Rheumatology 2004"Joint, muscle, and visceral pain: Long-term ablation of visceral pain after intrathecal resiniferatoxin" in The Journal of Pain 2005"Receptor for Advanced Glycation End Product (RAGE) Upregulation in Human Gingival Fibroblasts Incubated With Nornicotine" in Journal of Periodontology 2005"Use of a novel thermal operant behavioral assay for characterization of orofacial pain sensitivity" in Pain 2005"Peripheral targeting of the trigeminal ganglion via the infraorbital foramen as a therapeutic strategy" in Brain Research Protocols 2005"Spinal cord NR1 serine phosphorylation and NR2B subunit suppression following peripheral inflammation" in Molecular Pain 2005"Measurement of resiniferatoxin in serum samples by high-performance liquid chromatography" in Journal of Chromatography B 2005"Expression of the receptor of advanced glycation end products in gingival tissues of type 2 diabetes patients with chronic periodontal disease: a study utilizing immunohistochemistry and RT-PCR" in Journal of Clinical Periodontology 2005"Diverse immunocytochemical expression of opioid receptors in electrophysiologically defined cells of rat dorsal root ganglia" in Journal of Chemical Neuroanatomy 2005"Somatic hypersensitivity after TNBS induced colitis in rats" in The Journal of Pain 2006"Selective up-regulation of NMDA-NR1 receptor expression in myenteric plexus after TNBS induced colitis in rats" in Molecular Pain 2006"Memory in astrocytes: a hypothesis" in Theoretical Biology and Medical Modelling 2006"Differentiation between capsaicin-induced allodynia and hyperalgesia using a thermal operant assay" in Behavioural Brain Research 2006"Phosphorylation of NMDA NR1 subunits in the myenteric plexus during TNBS induced colitis" in Neuroscience Letters 2006"Characterization of cold sensitivity and thermal preference using an operant orofacial assay" in Molecular Pain 2007"Expression of the Receptor of Advanced Glycation End Products in the Gingival Tissue of Smokers With Generalized Periodontal Disease and After Nornicotine Induction in Primary Gingival Epithelial Cells" in Journal of Periodontology 2007"Sensitization of spinal cord nociceptive neurons with a conjugate of substance P and cholera toxin" in BMC Neuroscience 2007"Expression of the N-methyl-d-aspartate receptor NR1 splice variants and NR2 subunit subtypes in the rat colon" in Neuroscience 2007"Effects of mu- and kappa-2 opioid receptor agonists on pain and rearing behaviors" in Behavioral and Brain Functions 2007"Visceral and somatic hypersensitivity in a subset of rats following TNBS-induced colitis" in Pain 2008"Visceral and Somatic Hypersensitivity in TNBS-Induced Colitis in Rats" in Digestive Diseases and Sciences 2008"RAGE mRNA Expression and Its Correlation with Nuclear Factor Kappa Beta mRNA Expression in Inflamed Human Periradicular Tissues" in Journal of Endodontics 2008"Decreased levels of soluble receptor for advanced glycation end products in patients with primary Sjögren’s syndrome" in Rheumatology International 2008"Characterization of mouse orofacial pain and the effects of lesioning TRPV1-expressing neurons on operant behavior" in Molecular Pain 2008"Bite force and pattern measurements for dental pain assessment in the rat" in Neuroscience Letters 2008"Identification and immunohistochemical characterization of colospinal afferent neurons in the rat" in Neuroscience 2008"Spinal NMDA NR-1 Expression Following Resolution of TNBS Colitis" in Gastroenterology 2009"Dose-Dependent Effects of Icilin on Thermal Preference in the Hindpaw and Face of Rats" in The Journal of Pain 2009"Spinal NMDA NR1 subunit expression following transient TNBS colitis" in Brain Research 2009"NMDA receptor subunit expression and PAR2 receptor activation in colospinal afferent neurons (CANs) during inflammation induced visceral hypersensitivity" in Molecular Pain 2009"Altered expression of spinal NMDA NR1 receptors in TNBS colitis" in The Journal of Pain 2010"Central Sensitization in the Trigeminal Nucleus Caudalis Produced by a Conjugate of Substance P and the A Subunit of Cholera Toxin" in The Journal of Pain 2011"Effect of caloric and non-caloric sweet reward solutions on thermal facial operant conditioning" in Behavioural Brain Research 2011"Adaptation of a novel operant orofacial testing system to characterize both mechanical and thermal pain" in Behavioural Brain Research 2011"Neural Modulation of Orthodontic Tooth Movement" in Principles in Contemporary Orthodontics 2011"Memory in Astrocytes: A Hypothesis" in Models and Applications of Chaos Theory in Modern Sciences 2012"Lesioning of TRPV1 expressing primary afferent neurons prevents PAR-2 induced motility, but not mechanical hypersensitivity in the rat colon" in Neurogastroenterology & Motility 2012"Morphine and MK-801 administration leads to alternative N-methyl-d-aspartate receptor 1 splicing and associated changes in reward seeking behavior and nociception on an operant orofacial assay" in Neuroscience 2012"Placebo-induced analgesia in an operant pain model in rats" in Pain 2012"Long-term changes in reward-seeking following morphine withdrawal are associated with altered N-methyl-d-aspartate receptor 1 splice variants in the amygdala" in Neuroscience 2012"Characterization of bilateral trigeminal constriction injury using an operant facial pain assay" in Neuroscience 2012"Opioid mediation of endogenous pain modulation methods in healthy controls and patients with Temporomandibular Disorder" in The Journal of Pain 2012"Tu1443 Altered Vasoactive Intestinal Peptide (VIP) Expression in Patients With Chronic Abdominal Pain (CAP)" in Gastroenterology 2013"Effects of diet-induced obesity on motivation and pain behavior in an operant assay" in Neuroscience 2013"Reduction of conditioned pain modulation in humans by naltrexone: an exploratory study of the effects of pain catastrophizing" in Journal of Behavioral Medicine 2013"Use of the Operant Orofacial Pain Assessment Device (OPAD) to Measure Changes in Nociceptive Behavior" in JoVE 2013"Anti-nociceptive effect of a conjugate of substance P and light chain of botulinum neurotoxin type A" in Pain 2014"The Effects of a Co-Application of Menthol and Capsaicin on Nociceptive Behaviors of the Rat on the Operant Orofacial Pain Assessment Device" in PLoS One 2014"Operant Assays for Assessing Pain in Preclinical Rodent Models: Highlights from an Orofacial Assay" in Behavioral Neurobiology of Chronic Pain 2014"Mild traumatic brain injury (mTBI) produces alteration in orofacial and peripheral pain in a rodent model" in Society for Neuroscience Meeting 2014"Operant Pain-Related Decisions and Disability in a Mouse Model of Migraine-Related Hypersensitivity" in Annual Meeting of the American Headache Society 2015"Altered vasoactive intestinal peptides expression in irritable bowel syndrome patients and rats with trinitrobenzene sulfonic acid-induced colitis" in World Journal of Gastroenterology 2015"A novel operant-based behavioral assay of mechanical allodynia in the orofacial region of rats" in Journal of Neuroscience Methods 2015"Phosphorylation of the N-methyl-d-aspartate receptor is increased in the nucleus accumbens during both acute and extended morphine withdrawal" in The Journal of Pharmacology and Experimental Therapeutics 2015"Ionic conjugates of lidocaine and sweeteners as better tasting local anesthetics for dentistry" in Journal of Materials Chemistry B 2015"Post-traumatic pain in a rodent model of mild-traumatic brain injury (mTBI) and treatment with transcranial magnetic stimulation (TMS)" in Society for Neuroscience Meeting 2016"Trigeminal neuroplasticity underlies allodynia in a preclinical model of mild closed head traumatic brain injury (cTBI)" in Neuropharmacology 2017"Sex differences in mouse Transient Receptor Potential Cation Channel, Subfamily M, Member 8 expressing trigeminal ganglion neurons" in PLoS One 2017"Advanced glycation endproducts (AGEs) in saliva of patients with multiple myeloma – a pilot study" in Leukemia & Lymphoma 2017"Effects of cocoa-enriched diet on orofacial pain in a murine model" in Orthodontics & Craniofacial Research 2018"Pain control through selective chemo-axotomy of centrally projecting TRPV1+ sensory neurons" in The Journal of Clinical Investigation 2018"Behavioral characteristics of capsaicin mediated cutaneous, myogenic, and arthrogenic orofacial nociception in rats" in Archives of Oral Biology 2018"Understanding Electric Pulp Testing" in Dentistry & Dental Practices Journal 2019"Alterations in Brain Functional Connectivity in an Animal Model of Colitis" in Gastroenterology 2020"Pharmacological Characterization of Orofacial Nociception in Female Rats Following Nitroglycerin Administration" in Frontiers in Pharmacology 2021"Editorial: Verification of Animal Pain Models by Reverse Translation" in Frontiers in Pharmacology 2022"Oxycodone decreases anxiety-like behavior in the elevated plus-maze test in male and female rats" in Behavioural Pharmacology 2022"Assessment of Nerve Injury-Induced Mechanical Hypersensitivity in Rats Using an Orofacial Operant Pain Assay" in JoVE 2022"Effects of Oxaliplatin on Facial Sensitivity to Cool Temperatures and TRPM8 Expressing Trigeminal Ganglion Neurons in Mice" in Frontiers in Pain Research 2023"Influence of TRPV1 on Thermal Nociception in Rats with Temporomandibular Joint Persistent Inflammation Evaluated by the Operant Orofacial Pain Assessment Device (OPAD)" in Journal of Pain Research 2023"Locus coeruleus-noradrenergic modulation of trigeminal pain: Implications for trigeminal neuralgia and psychiatric comorbidities" in Neurobiology of Pain 2023"An ethogram analysis of cutaneous thermal pain sensitivity and oxycodone reward-related behaviors in rats" in Scientific Reports 2024"Neuraxial Delivery of Targeted Toxins for Long-Term Pain Control" in Neuraxial Therapeutics 2024Pathway to Diagnosis and Management of Toothaches: A General Dentist’s Perspective 2025"Cannabidiol interactions with oxycodone analgesia in an operant orofacial cutaneous thermal pain assay following oral administration in rats" in Pharmacology Biochemistry and Behavior 2025"A standardized, open-source, portable model for noninvasive joint injury in mice" in Osteoarthritis and Cartilage Open 2025"Mitochondrial and Autophagy‐Related Proteins are Downregulated in the Brains of the rTg4510 Mouse Model of Tauopathy and Associated with Pain‐like Behavior in a Sex‐Dependent Manner" in Alzheimer's & Dementia 2025"Sex-related differences in cannabidiol's antinociceptive efficacy in a trigeminal neuralgia rodent model" in Pain 2025"Preclinical perspectives on disorders of the temporomandibular joint: Tracing the past, navigating the present, and shaping the future" in The Journal of Pain 2025"Identification of sensory fiber types in mouse temporomandibular joint tissues" in Scientific Reports 2026"Cannabidiol reduces oxycodone self-administration while preserving its analgesic efficacy in a rat model of neuropathic pain" in Scientific Reports